Analysis:
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Current Health and Preparation: Sinner's withdrawal from Cincinnati due to knee inflammation raises concerns about his physical readiness. Without recent competition since Wimbledon, there's limited data on his match fitness and form.
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Historical Performance and Ranking: Despite his current number 1 ranking and success on hard courts earlier in the season, the lack of recent play increases uncertainty about his early-round performance at the US Open.
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Rival Considerations: With Alcaraz's participation in doubt, one potential high-level threat may be diminished. However, other capable competitors like Djokovic and Zverev remain strong threats.
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Strategic Rest: While Sinner’s strategic rest approach could optimize his stamina for later stages, it does introduce unpredictability.
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Match Sharpness: The absence of recent competitive play increases uncertainty regarding his performance, especially during the initial rounds.
Conclusion:
Given these considerations, including health concerns and competitive factors, the probability for Sinner winning the US Open has been adjusted to 40%, reflecting the combination of his potential for excellence and the increased risks due to recent developments.
Jannik Sinner's probability of winning the US Open in 2026 needs to be assessed through multiple lenses:
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Current Form and Surface Aptitude: Sinner is in excellent form, having won Wimbledon and multiple Masters 1000 titles in 2026. His success on hard courts, where the US Open is played, is significant, as evidenced by his victories in Indian Wells and Miami, strengthening his case.
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Historical Performance: Sinner has a strong track record at the US Open, with a title in 2024 and a finals appearance in 2025, indicating a history of performing well at this venue.
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Competitive Landscape: A key challenge remains Carlos Alcaraz, a consistent rival. Despite Sinner's overall dominance, his head-to-head record against Alcaraz is poor (1–6 since early 2024), and this rivalry could be pivotal in deciding the outcome.
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Medical Considerations: The recent medical examination raises some concern but without significant evidence of injury, it remains a minor factor.
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Momentum and Confidence: Winning Wimbledon and being ranked No.1 suggests strong momentum, which is critical in a Grand Slam setting.
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Risk Factors: The surprise loss at Roland Garros signifies potential vulnerabilities either physically or mentally, and the recent medical check could hint at undisclosed issues.
Given these variables, Sinner has a strong chance but not overwhelming, as challenges, primarily from rivals like Alcaraz, remain substantial. Therefore, I assign a probability of 45% for Sinner winning the US Open 2026.